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Article

<i>p53</i>mutations in lung tumours: relationship to gender and lung DNA adduct levels

1 Jan 1996

Abstract excerpt

Human lung cancer exhibits a high frequency of transversion mutations at G:C base pairs of the p53 gene, possibly the result of DNA damage by cigarette smoke constituents, most notably benzo[a]pyrene. We have investigated gender differences in the p53 mutational spectrum and levels of hydrophobic DNA adducts. Tumour tissue was obtained from 115 non-small cell lung cancer tumours and examined for mutational...

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PMID: 8895489
DOI: 10.1093/carcin/17.10.2201

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