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Article

Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors.

International journal of cancer - 3 Jul 1996

Woloschak M, Yu A, Xiao J, Post K D

Abstract excerpt

Targeted disruptions of the retinoblastoma (Rb) gene result in a high frequency of pituitary tumors in heterozygous mice. While our group and others have reported that loss of heterozygosity (LOH) at the Rb locus in human pituitary tumors is rare, these studies have not excluded small inactivating Rb-gene abnormalities more frequently found in human tumors and undetectable by LOH-PCR assays. As a more sensitive...

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Source

Identifiers

PMID: 8690518
DOI: 10.1002/(SICI)1097-0215(19960703)67:1<16::AID-IJC4>3.0.CO;2-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors.PMID 8690518Read ↗

The retinoblastoma gene in human pituitary tumors.Semantic proximity Read ↗

Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.Semantic proximity Read ↗

Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.Semantic proximity Read ↗

Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.Semantic proximity Read ↗

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.Semantic proximity Read ↗

Mutation spectrum of the retinoblastoma gene in osteosarcomas.Semantic proximity Read ↗

Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors.Semantic proximity Read ↗

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.Semantic proximity Read ↗

The p15<sup>INK4b</sup>/p16<sup>INK4a</sup>/RB1 Pathway Is Frequently Deregulated in Human Pituitary AdenomasSemantic proximity Read ↗

Altered Expression of the Retinoblastoma Gene Product in Human SarcomasSemantic proximity Read ↗

Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function.Semantic proximity Read ↗

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma.Semantic proximity Read ↗

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