Article
Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors.
Oncogene - 1 May 1994
Kratzke R A, Otterson G A, Hogg A, Coxon A B, Geradts J, Cowell J K, Kaye F J
Abstract excerpt
While familial retinoblastoma has served as the paradigm for the two-hit theory of tumorigenesis and for the concept of the tumor suppressor gene, the etiology of incomplete penetrance of familial retinoblastoma is poorly understood. To address the molecular basis for this phenotype we have studi...
Topics
- Alleles
- Base Sequence
- Eye Neoplasms
- Family
- Genes, Retinoblastoma
- Humans
- Molecular Sequence Data
- Phenotype
- Phosphorylation
- Point Mutation
- Retinoblastoma
- Retinoblastoma Protein
- Tumor Cells, Cultured