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Article

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma.

Cancer medicine - 1 Mar 2017

Ewens Kathryn G, Bhatti Tricia R, Moran Kimberly A, Richards-Yutz Jennifer, Shields Carol L, Eagle Ralph C, Ganguly Arupa

Abstract excerpt

A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the mutation status of the RB1 gene and MYCN copy number in a series of 245 unilateral retinoblastomas, and the...

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Share to Gene Amplification
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to N-Myc Proto-Oncogene Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 28211617
DOI: 10.1002/cam4.1010
PMCID: PMC5345671

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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