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Article

Mutation spectrum of the retinoblastoma gene in osteosarcomas.

Cancer research - 1 Jun 1994

Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki M S, Kotoura Y, Yamamuro T

Abstract excerpt

We have performed an intensive mutation survey of the Rb gene in 63 osteosarcomas. Loss of heterozygosity (LOH) at the Rb locus was analyzed by using polymerase chain reaction at four intronic polymorphic sites, and 62.9% (39 of 62) of tumors showed LOH. Mutation analysis of the Rb gene was perfo...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
Bone Neoplasms
Child
Child, Preschool
Gene Deletion
Genes, Retinoblastoma
Humans
Lung Neoplasms
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Osteosarcoma

Polymerase Chain Reaction

Prognosis

Source

Identifiers

PMID: 8187094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8187094-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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