Article
Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.
Oncogene - 1 Apr 1994
Hu N, Gutsmann A, Herbert D C, Bradley A, Lee W H, Lee E Y
Abstract excerpt
Humans with a germline mutation of the RB gene are predisposed to retinoblastoma with a 90% penetrance and are at higher risk for other rare tumors. We have established a mouse strain carrying a germ-line mutation of the Rb-1 gene. Here we describe a nearly 100% incidence of spontaneous pituitary...
Topics
- Age Factors
- Animals
- Biomarkers, Tumor
- Chromosome Deletion
- Disease Susceptibility
- Genes, Retinoblastoma
- Heterozygote
- Immunohistochemistry
- Mice
- Mice, Mutant Strains
- Mutation
- Pituitary Neoplasms
- Retinoblastoma Protein
- alpha-MSH