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User-Friendly Reverse Genetics System for Modification of the Right End of Fowl Adenovirus 4 Genome

11 Mar 2020

Abstract excerpt

A novel fowl adenovirus 4 (FAdV-4) has caused significant economic losses to the poultry industry in China since 2015. We established an easy-to-use reverse genetics system for modification of the whole right and partial left ends of the novel FAdV-4 genome, which worked through cell-free reactions of restriction digestion and Gibson assembly. Three recombinant viruses were constructed to test the assumption that...

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PMID: 32168853
DOI: 10.3390/v12030301

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