Characterization of hepatitis B virus core mutants that inhibit viral replication.

doi:10.1006/viro.1994.1625

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Article

Characterization of hepatitis B virus core mutants that inhibit viral replication.

Virology - 15 Nov 1994

Scaglioni P P, Melegari M, Wands J R

Abstract excerpt

We have generated and functionally characterized dominant negative core protein variants of the hepadnaviruses to determine their effects on "wild type" viral replication. Plasmids expressing these constructs were introduced into hepatoma cell lines by transient transfection and effects on wild t...

Topics

DNA Replication
DNA, Viral
Genes, Viral
Hepatitis B Virus, Woodchuck
Hepatitis B virus
Humans
Mutation
Tumor Cells, Cultured
Viral Core Proteins
Virus Replication

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