Article
Undectable expression of hMLH1 protein in sporadic colorectal cancer with replication error phenotype.
Diseases of the colon and rectum - 1 Oct 1997
Koike J, Yamada K, Takano S, Kikuchi Y, Hemmi H, Koi M, Tsujita K, Yanagita K, Yoshio T, Shimatake H
Abstract excerpt
PURPOSE: Four DNA mismatch repair genes have been identified as being susceptible genes for hereditary nonpolyposis colorectal cancer. Deficiency of one of the mismatch repair genes causes the replication error phenotype in more than 80 percent of patients with hereditary nonpolyposis colorectal...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA, Neoplasm
- DNA-Binding Proteins
- Humans
- Immunoblotting
- Microsatellite Repeats
- Middle Aged
- MutL Protein Homolog 1
- MutS Homolog 2 Protein
- Neoplasm Proteins