Article
Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors.
Cancer - 15 Jan 1998
Senba S, Konishi F, Okamoto T, Kashiwagi H, Kanazawa K, Miyaki M, Konishi M, Tsukamoto T
Abstract excerpt
BACKGROUND: DNA replication errors (RERs) are closely associated with hereditary nonpolyposis colorectal carcinoma (HNPCC). Recently, alterations in DNA mismatch repair genes, including hMSH2, hMLH1, and hPMS2, have been implicated in the pathogenesis of HNPCC: Several studies have demonstrated R...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma
- Carrier Proteins
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Primers
- DNA Repair Enzymes
- DNA Replication
- DNA, Neoplasm
- DNA-Binding Proteins
- Exons
- Female