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Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors.

Cancer - 15 Jan 1998

Senba S, Konishi F, Okamoto T, Kashiwagi H, Kanazawa K, Miyaki M, Konishi M, Tsukamoto T

Abstract excerpt

BACKGROUND: DNA replication errors (RERs) are closely associated with hereditary nonpolyposis colorectal carcinoma (HNPCC). Recently, alterations in DNA mismatch repair genes, including hMSH2, hMLH1, and hPMS2, have been implicated in the pathogenesis of HNPCC: Several studies have demonstrated RER in 13-17% of nonfamilial colorectal carcinomas. It is unclear, however, as to whether or not these RER positive...

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PMID: 9445183

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