Genetic control of the human V beta 13.2 T cell repertoire: importance of allelic variation outside the coding regions of the TCRBV13S2 gene.

doi:10.1002/eji.1830241142

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Article

Genetic control of the human V beta 13.2 T cell repertoire: importance of allelic variation outside the coding regions of the TCRBV13S2 gene.

European journal of immunology - 1 Nov 1994

Kay R A, Snowden N, Hajeer A H, Boylston A W, Ollier W E

Abstract excerpt

In humans, the T cell repertoire is influenced by HLA, T cell receptor null alleles and antigen. Here, we describe a novel mechanism, independent of superantigen or T cell receptor structure which influences the T cell repertoire in a V beta-dependent manner. We have identified a biallelic locus,...

Topics

Alleles
Base Sequence
Chromosome Mapping
Genotype
Humans
Molecular Sequence Data
Receptors, Antigen, T-Cell, alpha-beta

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