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Article

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.

Cell - 11 Jan 1991

Rogge R D, Karlovich C A, Banerjee U

Abstract excerpt

We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles of Sos are recessive lethals, but in the eye Sos has a role in R cell development. Mutations in Sos also interact with...

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Source

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PMID: 1846090
DOI: 10.1016/0092-8674(91)90207-f

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.PMID 1846090Read ↗

The Son of sevenless gene product: a putative activator of Ras.Semantic proximity Read ↗

Understanding SOS (Son of Sevenless).Semantic proximity Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila.Semantic proximity Read ↗

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.Semantic proximity Read ↗

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.Semantic proximity Read ↗

The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination.Semantic proximity Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.Semantic proximity Read ↗

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

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