Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.

doi:10.1016/0092-8674(91)90207-f

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Article

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.

Cell - 11 Jan 1991

Rogge R D, Karlovich C A, Banerjee U

Abstract excerpt

We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles o...

Topics

Alleles
Animals
Chromosome Mapping
Drosophila
ErbB Receptors
Eye
Genes, Recessive
Genes, Suppressor
Genetic Complementation Test
Genotype
Models, Genetic
Mosaicism
Phenotype
Protein-Tyrosine Kinases

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