Article
Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Jun 1996
Wang Z, Morris G F, Rice A P, Xiong W, Morris C B
Abstract excerpt
SUMMARY: Tat regulates human immunodeficiency virus type 1 (HIV-1) gene expression by increasing both the rate of transcription initiation and the efficiency of transcription elongation. The ability of Tat to facilitate HIV-1 transcription preinitiation complex formation suggests that components...
Topics
- Binding Sites
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Gene Products, tat
- Glutathione Transferase
- HIV-1
- Humans
- In Vitro Techniques
- Mutagenesis, Site-Directed
- Mutation
- Protein Binding
- Recombinant Fusion Proteins
- Sequence Deletion