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Chromatin Remodeling and Modification during HIV-1 Tat-activated Transcription

1 Jul 2003

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS. Following entry into the host cell, the viral RNA is reverse transcribed into DNA and subsequently integrated into the host genome as a chromatin template. Chromatin structure may be responsible for silencing retroviral gene expression. Transcriptional activation occurs after ATP-dependent chromatin remodeling complexes alter chromatin...

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PMID: 15046258
DOI: 10.2174/1570162033485186

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