Article
Direct interaction of human TFIID with the HIV-1 transactivator tat.
Nature - 20 Jan 1994
Kashanchi F, Piras G, Radonovich M F, Duvall J F, Fattaey A, Chiang C M, Roeder R G, Brady J N
Abstract excerpt
The tat gene of the human immunodeficiency virus (HIV) plays a central role in the activation and life cycle of HIV. The tat protein (Tat) specifically transactivates HIV transcription in vivo and in vitro, exerting its effects at the level of transcriptional initiation and elongation. Here we report that Tat binds directly to the basal transcription factor TFIID. The transcriptional activity of HeLa extracts was...
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