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Article

Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain?

Virology - 1 Oct 1990

Tiley L S, Brown P H, Cullen B R

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) encodes a transcriptional trans-activator, termed Tat, that is absolutely required for viral replication in vitro. By analogy to other known transcription factors, it has been suggested that the HIV-1 Tat protein may contain discrete protein domains that determine sequence specificity and transcriptional activation potential. Here, we report the use of site-directed...

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Identifiers

PMID: 2219707
DOI: 10.1016/0042-6822(90)90354-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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