Article
Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.
Journal of molecular biology - 7 Jul 1995
Veschambre P, Simard P, Jalinot P
Abstract excerpt
Tat strongly activates transcription of the HIV-1 provirus by stimulating both initiation and elongation. This transactivator binds to the TAR RNA element, but can also associate with cellular transcription factors, interacting with upstream promoter sequences. To achieve a better understanding of the role of Tat in the assembly of the transcriptional initiation complex in the living cell, we have examined how...
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