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Article

CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes.

Retrovirology - 26 Jul 2012

Wilhelm Emmanuelle, Doyle Marie-Christine, Nzaramba Isaac, Magdzinski Alexandre, Dumais Nancy, Bell Brendan

Abstract excerpt

BACKGROUND: HIV latency is an obstacle for the eradication of HIV from infected individuals. Stable post-integration latency is controlled principally at the level of transcription. The HIV trans-activating protein, Tat, plays a key function in enhancing HIV transcriptional elongation. The HIV core promoter is specifically required for Tat-mediated trans-activation of HIV transcription. In addition, the HIV core...

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Share to Electrophoretic Mobility Shift Assay
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, tat

Share to HIV Long Terminal Repeat

Share to Leukocytes, Mononuclear

Share to Multiprotein Complexes

Share to Nucleotide Motifs

Source

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Identifiers

PMID: 22834489
DOI: 10.1186/1742-4690-9-62
PMCID: PMC3419132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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