K-ras mutations and HLA-DR expression in large bowel adenomas.

doi:10.1038/bjc.1996.322

Article

K-ras mutations and HLA-DR expression in large bowel adenomas.

British journal of cancer - 1 Jul 1996

Norheim Andersen S, Breivik J, Løvig T, Meling G I, Gaudernack G, Clausen O P, Schjölberg A, Fausa O, Langmark F, Lund E, Rognum T O

Abstract excerpt

A total of 72 sporadic colorectal adenomas in 56 patients were studied for the presence of point mutations in codons 12 and 13 of the K-ras gene and for HLA-DR antigen expression related to clinicopathological variables. Forty K-ras mutations in 39 adenomas were found (54%): 31 (77%) in codon 12...

Topics

Adenoma
Adult
Aged
Aged, 80 and over
Base Sequence
Colorectal Neoplasms
Epithelium
Female
Genes, ras
HLA-DR Antigens
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Up-Regulation

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