Article
K-ras mutations and HLA-DR expression in large bowel adenomas.
British journal of cancer - 1 Jul 1996
Norheim Andersen S, Breivik J, Løvig T, Meling G I, Gaudernack G, Clausen O P, Schjölberg A, Fausa O, Langmark F, Lund E, Rognum T O
Abstract excerpt
A total of 72 sporadic colorectal adenomas in 56 patients were studied for the presence of point mutations in codons 12 and 13 of the K-ras gene and for HLA-DR antigen expression related to clinicopathological variables. Forty K-ras mutations in 39 adenomas were found (54%): 31 (77%) in codon 12 and nine (23%) in codon 13. There was a strong relationship between the incidence of K-ras mutations and adenoma type,...
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