Article
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
Archives of biochemistry and biophysics - 1 May 1994
Kim H, Yang X L, Rosada C, Hamilton S R, August J T
Abstract excerpt
Neoplastic progression of colorectal epithelial cells from benign adenomas to malignant carcinomas appears to result from a series of genetic alterations involving both oncogenes and tumor suppressor genes. This progression was recently found to be associated with expression of splice variant isoforms of CD44, a cell surface hyaluronate receptor implicated in carcinogenesis. In this study we examined the...
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