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Article

K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.

European journal of cancer (Oxford, England : 1990) - 1 Dec 1998

Zhang H, Nordenskjöld B, Dufmats M, Söderkvist P, Sun X F

Abstract excerpt

The K-ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa (n = 106), transitional mucosa (n = 69) and tumours (n = 149) from 149 patients with colorectal adenocarcinomas. K-ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, but not in the normal mucosa. Further, mutation rates were...

Topics

Adenocarcinoma, Mucinous
Aged
Aged, 80 and over
Codon
Colorectal Neoplasms
DNA, Neoplasm
Female
Genes, ras
Humans
Intestinal Mucosa
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ploidies

Polymerase Chain Reaction

Source

Identifiers

PMID: 10070310
DOI: 10.1016/s0959-8049(98)00283-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10070310-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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