Article
Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line.
Mutation research - 10 Jun 1996
Carrier F, Bae I, Smith M L, Ayers D M, Fornace A J
Abstract excerpt
We have previously reported that WI-L2-NS, a human lymphoblastoid cell line, has very high basal levels of GADD45 mRNA and protein in spite of a p53 mutation at amino acid 237. Regardless of the amount of Gadd45 in this cell line, no growth suppression activity was detected. We report here that i...
Topics
- Alkylating Agents
- Binding Sites
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA
- Gene Expression Regulation
- Humans
- Intracellular Signaling Peptides and Proteins
- Introns
- Lymphocytes
- Methyl Methanesulfonate
- Mutation
- Nuclear Proteins
- Protein Conformation
- Proteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2