Article
The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status.
Mutation research - 1 Feb 1995
Zhen W, Denault C M, Loviscek K, Walter S, Geng L, Vaughan A T
Abstract excerpt
The lymphoblastoid cell lines WI-L2-NS and TK6 were derived from a non-clonal pool of cells taken from a human spleen. Despite their common background they exhibit marked differences in radiosensitivities; D0 values of 93 and 67 cGy have been reported for WI-L2-NS and TK6 cells respectively. We s...
Topics
- Apoptosis
- Base Sequence
- Blotting, Western
- Cell Line
- DNA Damage
- Dose-Response Relationship, Radiation
- Gamma Rays
- Humans
- Lymphocytes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Precipitin Tests
- Radiation Tolerance
- Sequence Analysis, DNA
- Tumor Suppressor Protein p53