Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.

doi:10.1083/jcb.143.7.2057

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.

The Journal of cell biology - 28 Dec 1998

Decoster E, Cornelis S, Vanhaesebroeck B, Fiers W

Abstract excerpt

Tumor necrosis factor (TNF) and lymphotoxin (LT) alpha are structurally and functionally related cytokines. We expressed the TNF and LT-alpha genes in murine fibrosarcoma L929r2 cells, which can be sensitized to TNF/LT-alpha-dependent necrosis by inhibitors of transcription or translation. Autocrine production of murine TNF in L929r2 cells completely downmodulated the expression of the 55- and 75-kD TNF...

Topics

Animals
Antigens, CD
Biological Transport
Cell Membrane
Cytotoxicity, Immunologic
Down-Regulation
Drug Resistance
Fibrosarcoma
Gene Expression Regulation
Lymphotoxin-alpha
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Sorting Signals

Receptors, Tumor Necrosis Factor

Receptors, Tumor Necrosis Factor, Type I

Receptors, Tumor Necrosis Factor, Type II

Recombinant Fusion Proteins

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 9864375
DOI: 10.1083/jcb.143.7.2057
PMCID: PMC2175230

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.PMID 9864375Read ↗

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the gamesSemantic proximity Read ↗

Continuous autotropic signaling by membrane-expressed tumor necrosis factor.Semantic proximity Read ↗

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journeySemantic proximity Read ↗

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.Semantic proximity Read ↗

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral ProteinsSemantic proximity Read ↗

Mechanisms of tumor necrosis factor cytotoxicity and the cytotoxic signals transduced by the p75-tumor necrosis factor receptor.Semantic proximity Read ↗

Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor.Semantic proximity Read ↗

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.Semantic proximity Read ↗

Production and characterization of receptor-specific TNF muteins.Semantic proximity Read ↗

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact.Semantic proximity Read ↗

Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.