Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis.

Biological & pharmaceutical bulletin - 1 Apr 2000

Han S Y, Choung S Y, Paik I S, Kang H J, Choi Y H, Kim S J, Lee M O

Abstract excerpt

Tumor necrosis factor alpha (TNFalpha) generates a potent cytotoxic effect, however many cancer cells are resistant to TNFalpha-mediated killing and the cause of the differential sensitivity remains to be elucidated. In this study, we demonstrated that TNFalpha induced cell death in four different human colon cancer cell lines. The degree of cytotoxic effect was different in each cell line, in that HCT-15 was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to NF-KappaB Inhibitor alpha
Share to Apoptosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to DNA Primers

Share to I-kappa B Proteins

Share to NF-kappa B

Share to Tumor Cells, Cultured

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 10784420
DOI: 10.1248/bpb.23.420

Genes

DLD
FADD
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis.PMID 10784420Read ↗

Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells.Semantic proximity Read ↗

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.Semantic proximity Read ↗

IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.Semantic proximity Read ↗

Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer CellsSemantic proximity Read ↗

TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell deathSemantic proximity Read ↗

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene ExpressionSemantic proximity Read ↗

BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB.Semantic proximity Read ↗

Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic ApproachSemantic proximity Read ↗

Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.Semantic proximity Read ↗

Thymineless death in colon carcinoma cells is mediated via Fas signalingSemantic proximity Read ↗

5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteinsSemantic proximity Read ↗

The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.