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Article

Enhanced sensitivity of human colon tumor cell lines in vitro in response to thermochemoimmunotherapy.

Cancer research - 1 Oct 1992

Klostergaard J, Leroux E, Siddik Z H, Khodadadian M, Tomasovic S P

Abstract excerpt

We have investigated the cytotoxic responses in vitro of three human colon tumor cell lines with epithelial-like morphology, DLD-1, HCT-15, and HT-29, to thermochemoimmunotherapy with hyperthermia (42 degrees C for 2 h), carboplatin, and recombinant human tumor necrosis factor (TNF). Dose ranges of carboplatin and recombinant human TNF were administered essentially simultaneously and were followed 1 h later by...

Topics

Adenocarcinoma
Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Colonic Neoplasms
Combined Modality Therapy
Humans
Hyperthermia, Induced
Immunologic Factors
Immunotherapy
Neutral Red
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Tumor Stem Cell Assay

Source

Identifiers

PMID: 1394131

Genes

TNF
DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1394131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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