Mechanisms of tumor necrosis factor cytotoxicity and the cytotoxic signals transduced by the p75-tumor necrosis factor receptor.

Article

Mechanisms of tumor necrosis factor cytotoxicity and the cytotoxic signals transduced by the p75-tumor necrosis factor receptor.

Circulatory shock - 1 Oct 1994

Reid T, Louie P, Heller R A

Abstract excerpt

We have here provided evidence that TNF mediated cytotoxicity is genetically, pharmacologically, and temporally distinct from the cytotoxicity mediated by TNF/CHX. Most studies on TNF cytotoxicity have been done by the combined use of TNF/CHX. The relevance of this approach to the physiological m...

Topics

Animals
Antigens, CD
Cell Death
Cycloheximide
HeLa Cells
Humans
Neoplasms, Experimental
Phenotype
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type II
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha

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