Article
Exclusion of 5-HT2A and 5-HT2C receptor genes as candidate genes for migraine.
Headache - 1 Apr 1996
Buchwalder A, Welch S K, Peroutka S J
Abstract excerpt
Several lines of investigation suggest that the serotonergic system may be involved in the pathogenesis of migraine. In particular, drugs which block 5-HT2 receptor subtypes appear to be effective migraine prophylactic agents. Therefore, chromosomal DNA regions overlapping the 5-HT2A (13q14-q22) and 5-HT2C(Xq22-25) receptor loci were analyzed for possible linkage to the clinical diagnosis of migraine. No evidence...
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