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Article

Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2010

Jung Alexander, Huge Andreas, Kuhlenbäumer Gregor, Kempt Steffi, Seehafer Tanja, Evers Stefan, Berger Klaus, Marziniak Martin

Abstract excerpt

The serotonergic system plays a major role in the etiology of migraine. The rate-limiting enzyme in serotonin homeostasis and availability is tryptophan hydroxylase (TPH). The TPH2 isoform is responsible for the cerebral serotonin biosynthesis. To investigate the role of genetic variation in TPH2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20740293
DOI: 10.1007/s00702-010-0468-6

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20740293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.PMID 20740293Read ↗

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Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

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