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Article

Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2009

Marziniak Martin, Kienzler Claudia, Kuhlenbäumer Gregor, Sommer Claudia, Mössner Rainald

Abstract excerpt

Serotonin (5-HT) plays an important role in the pathophysiology of migraine. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of 5-HT in the brain and is therefore a major factor in the availability of 5-HT and its rate of production. We hypothesized that functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19434366
DOI: 10.1007/s00702-009-0236-7

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19434366-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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