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Article

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Cell cycle (Georgetown, Tex.) - 15 May 2009

Ahn Jinwoo, Poyurovsky Masha V, Baptiste Nicole, Beckerman Rachel, Cain Christine, Mattia Melissa, McKinney Kristine, Zhou Jianmin, Zupnick Andrew, Gottifredi Vanesa, Prives Carol

Abstract excerpt

Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutants were generated that changed core domain histidine residues. Of these mutants, only one, H115N p53, showed markedly reduced exonuclease activity (ca. 15% of wild-type). Surprisingly, purified H115N p53 protein was found...

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Source

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Identifiers

PMID: 19462533
DOI: 10.4161/cc.8.10.8548
PMCID: PMC2898518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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