Article
Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q.
Oncogene - 26 Apr 2001
Yin Z, Babaian R J, Troncoso P, Strom S S, Spitz M R, Caudell J J, Stein J D, Kagan J
Abstract excerpt
We studied loss of heterozygosity (LOH) on the long arm of human chromosome 18 in prostate cancer to determine the location of a putative tumor suppressor gene (TSG) and to correlate these losses with the pathological grade and stage of the cancer. Of 48 specimens analysed 17 (35.4%) lost at least one allele on chromosome 18q. All the specimens with allelic losses lost at least one allele within chromosomal...
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