Article
Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2002
Cunliffe Vincent T, Furley Andrew J W, Keenan Deborah
Abstract excerpt
In this paper we describe the production and analysis of mice carrying a 110-kb transgene that encompasses the wild-type Foxn1 genomic locus. Mutations in Foxn1 cause the nude phenotype. We show that in the hair follicles, transgenic mice with increased Foxn1 gene dosage exhibited increased Foxn1 expression that was restricted correctly to the nascent, post-mitotic cells of the differentiating hair cortex and...
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