Evidence for a NIMA-like mitotic pathway in vertebrate cells.

doi:10.1016/0092-8674(95)90394-1

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Article

Evidence for a NIMA-like mitotic pathway in vertebrate cells.

Cell - 5 May 1995

Lu K P, Hunter T

Abstract excerpt

NIMA is essential for entry into mitosis in Aspergillus nidulans. To examine whether there is a NIMA-like pathway in other eukaryotic cell cycles, we expressed NIMA and its dominant negative mutants in two different eukaryotic systems. In Xenopus oocytes, NIMA induced germinal vesicle breakdown without activating Mos, CDC2, or MAP kinase. In HeLa cells, NIMA induced premature mitotic events without activating...

Topics

Amino Acid Sequence
Animals
Aspergillus nidulans
CDC2 Protein Kinase
Calcium-Calmodulin-Dependent Protein Kinases
Cell Compartmentation
Cell Cycle
Cell Cycle Proteins
Cell Nucleus
Chromatin
Female
G2 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

HeLa Cells

Humans

Mitosis

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 7736593
DOI: 10.1016/0092-8674(95)90394-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7736593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for a NIMA-like mitotic pathway in vertebrate cells.PMID 7736593Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans.Semantic proximity Read ↗

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Semantic proximity Read ↗

Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.Semantic proximity Read ↗

Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.Semantic proximity Read ↗

A NIMA homologue promotes chromatin condensation in fission yeast.Semantic proximity Read ↗

Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.Semantic proximity Read ↗

Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation.Semantic proximity Read ↗

PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.Semantic proximity Read ↗

Mitotic regulation in Aspergillus nidulans.Semantic proximity Read ↗

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