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Article

Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.

Genetics - 1 Feb 1993

Longhese M P, Jovine L, Plevani P, Lucchini G

Abstract excerpt

Different pri1 and pri2 conditional mutants of Saccharomyces cerevisiae altered, respectively, in the small (p48) and large (p58) subunits of DNA primase, show an enhanced rate of both mitotic intrachromosomal recombination and spontaneous mutation, to an extent which is correlated with the severity of their defects in cell growth and DNA synthesis. These effects might be attributable to the formation of nicked...

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Identifiers

PMID: 8436268
DOI: 10.1093/genetics/133.2.183
PMCID: PMC1205309

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