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Article

Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1991

Francesconi S, Longhese M P, Piseri A, Santocanale C, Lucchini G, Plevani P

Abstract excerpt

To assess the role of eukaryotic DNA primase in vivo, we have produced conditional and lethal point mutations by random in vitro mutagenesis of the PR11 and PR12 genes, which encode the small and large subunits of yeast DNA primase. We replaced the wild-type copies of PRI1 and PRI2 with two pri1 and two pri2 conditional alleles. When shifted to the restrictive temperature, these strains showed altered DNA...

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Identifiers

PMID: 2023935
DOI: 10.1073/pnas.88.9.3877
PMCID: PMC51556

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Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.PMID 2023935Read ↗

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