T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.

doi:10.1084/jem.183.4.1669

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Article

T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.

The Journal of experimental medicine - 1 Apr 1996

Kalams S A, Johnson R P, Dynan M J, Hartman K E, Harrer T, Harrer E, Trocha A K, Blattner W A, Buchbinder S P, Walker B D

Abstract excerpt

Numerous virus-specific, class I-restricted cytotoxic T lymphocyte (CTL) epitopes have been identified, yet little information is available regarding the specificity of the CTL response in persons of the same human histocompatibility leukocyte antigen (HLA) type. In this study, the human immunode...

Topics

Amino Acid Sequence
Antigens, Viral
Base Sequence
Clone Cells
Genetic Variation
HIV Envelope Protein gp41
HIV Infections
HIV-1
HLA-B Antigens
HLA-B14 Antigen
Histocompatibility Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunodominant Epitopes

Male

Molecular Sequence Data

Peptide Fragments

Receptors, Antigen, T-Cell, alpha-beta

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 8666925
DOI: 10.1084/jem.183.4.1669
PMCID: PMC2192525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8666925-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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