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Article

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.

The Journal of cell biology - 21 Feb 2000

Farr G H, Ferkey D M, Yost C, Pierce S B, Weaver C, Kimelman D

Abstract excerpt

Glycogen synthase kinase 3 (GSK-3) is a constitutively active kinase that negatively regulates its substrates, one of which is beta-catenin, a downstream effector of the Wnt signaling pathway that is required for dorsal-ventral axis specification in the Xenopus embryo. GSK-3 activity is regulated through the opposing activities of multiple proteins. Axin, GSK-3, and beta-catenin form a complex that promotes the...

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Source

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Identifiers

PMID: 10684251
DOI: 10.1083/jcb.148.4.691
PMCID: PMC2169372

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.PMID 10684251Read ↗

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