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Article

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Dominguez I, Itoh K, Sokol S Y

Abstract excerpt

The dorsoventral axis is established early in Xenopus development and may involve signaling by Wnts, a family of Wnt1-protooncogene-related proteins. The protein kinase shaggy functions in the wingless/Wnt signaling pathway, which operates during Drosophila development. To assess the role of a closely related kinase, glycogen synthase kinase 3 beta (GSK-3 beta), in vertebrate embryogenesis, we cloned a cDNA...

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Identifiers

PMID: 7667318
DOI: 10.1073/pnas.92.18.8498
PMCID: PMC41184

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