Article
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
Nature - 13 Apr 1995
He X, Saint-Jeannet J P, Woodgett J R, Varmus H E, Dawid I B
Abstract excerpt
Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas...
Topics
- Animals
- Blastocyst
- Calcium-Calmodulin-Dependent Protein Kinases
- Embryo, Nonmammalian
- Embryonic Development
- Embryonic Induction
- Fibroblast Growth Factor 2
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Humans
- Molecular Sequence Data