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Article

Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase.

Development (Cambridge, England) - 1 Dec 1995

Itoh K, Tang T L, Neel B G, Sokol S Y

Abstract excerpt

Shaggy is a downstream component of the wingless and Notch signaling pathways which operate during Drosophila development. To address the role of glycogen synthase kinase 3 beta (GSK3 beta), a mammalian homologue of Shaggy, in vertebrate embryogenesis, it was overexpressed in Xenopus embryos. Microinjection of rat GSK3 beta mRNA into animal ventral blastomeres of 8-cell-stage embryos triggered development of...

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PMID: 8575298
DOI: 10.1242/dev.121.12.3979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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