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Article

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

The Journal of experimental medicine - 1 Jun 1996

Lee M S, Mueller R, Wicker L S, Peterson L B, Sarvetnick N

Abstract excerpt

Contrary to expectations based on in vitro experiments, we previously found that pancreatic IL-10 did not inhibit autoimmune diabetes but accelerated it in an MHC-dependent manner. Therefore, the ability of IL-10 to overcome the absence of all non-MHC diabetes susceptibility (Idd) alleles was studied in transgenic mice expressing pancreatic IL-10 backcrossed to B10.H2g7 congenic mice, which have no Idd alleles...

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Identifiers

PMID: 8676087
DOI: 10.1084/jem.183.6.2663
PMCID: PMC2192620

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Source receipt: pubmed, retrieved 7 Sept 2026.

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IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.PMID 8676087Read ↗

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