Article
Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 1994
Schumacher T N, Kantesaria D V, Serreze D V, Roopenian D C, Ploegh H L
Abstract excerpt
The TAP complex transports peptides from the cytosol into the lumen of the endoplasmic reticulum for presentation by major histocompatibility complex class I molecules. A limited degree of sequence polymorphism has been observed for the mouse TAP1 and TAP2 genes by restriction fragment length polymorphism and sequence analysis. However, functional polymorphism of the TAP transporter has thus far been observed for...
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