Biological and clinical importance of the p53 tumor suppressor gene.

Article

Biological and clinical importance of the p53 tumor suppressor gene.

Clinical chemistry - 1 Jun 1996

Velculescu V E, El-Deiry W S

Abstract excerpt

The p53 tumor suppressor gene controls cellular growth after DNA damage through mechanisms involving growth arrest and apoptosis. Mutations that inactivate p53 occur commonly in virtually all human malignancies and can be detected by sequencing of the p53 gene, immunohistochemical staining of tum...

Topics

Animals
Genes, p53
Genetic Therapy
Humans
Mutation
Neoplasms
Prognosis
Tumor Suppressor Protein p53

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