Article
Biological and clinical importance of the p53 tumor suppressor gene.
Clinical chemistry - 1 Jun 1996
Velculescu V E, El-Deiry W S
Abstract excerpt
The p53 tumor suppressor gene controls cellular growth after DNA damage through mechanisms involving growth arrest and apoptosis. Mutations that inactivate p53 occur commonly in virtually all human malignancies and can be detected by sequencing of the p53 gene, immunohistochemical staining of tumor tissue with anti-p53 antibodies, single-strand conformation polymorphisms, or other biological assays....
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