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CLINICAL IMPLICATIONS OF THE p53 GENE

1 Feb 1996

Abstract excerpt

The capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth and tissue homeostasis. Although several hundred genes are known to control growth, molecular genetic studies in cancer show that few of these are consistently involved in the natural history of human cancer, and those typically in only certain types of malignancy. Prospects for...

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PMID: 8712782
DOI: 10.1146/annurev.med.47.1.285

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