Article
The p53 tumor suppressor gene: from molecular biology to clinical investigation.
Annals of the New York Academy of Sciences - 1 Jun 2000
Soussi T
Abstract excerpt
The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transactivational properties of p53, which activate a series of genes involved in cell cycle regulation....
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