p53: the attractive tumor suppressor in the cancer research field.

Abstract excerpt

p53 is one of the most studied tumor suppressors in the cancer research field. Of note, over 50% of human tumors carry loss of function mutations, and thus p53 has been considered to be a classical Knudson-type tumor suppressor. From the functional point of view, p53 is a nuclear transcription factor to transactivate a variety of its target genes implicated in the induction of cell cycle arrest, DNA repair, and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genes, p53
• Share to Mice
• Share to Mutation