Detection of a mutator phenotype in cancer cells by inter-Alu polymerase chain reaction.

Article

Detection of a mutator phenotype in cancer cells by inter-Alu polymerase chain reaction.

Cancer research - 15 Jun 1996

Krajinovic M, Richer C, Labuda D, Sinnett D

Abstract excerpt

A mutator phenotype due to a DNA mismatch repair deficiency is usually detected by typing a number of microsatellite markets. Here, eight hereditary nonpolyposis colon cancer patients with microsatellite instability were investigated by inter-Alu PCR, known to amplify DNA segments that may repres...

Topics

Base Sequence
Colorectal Neoplasms, Hereditary Nonpolyposis
Humans
Molecular Sequence Data
Mutation
Phenotype
Polymerase Chain Reaction

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