Article
Detection of microsatellite instability in cancers by arbitrarily primed-PCR fingerprinting using a fluorescently labeled primer (FAP-PCR).
Biological chemistry - 1 Sept 1996
Yasuda J, Kashiwabara H, Kawakami K, Uematsu K, Sugano K, Perucho M, Sekiya T
Abstract excerpt
The microsatellite mutator phenotype (MMP), detected as a change in the number of repeating units in hundreds of thousands of microsatellite sequences in the tumor cell genome, underlies the carcinogenesis of a variety of tumors including sporadic and hereditary nonpolyposis colon cancers. This enhanced microsatellite instability was discovered using arbitrarily primed polymerase chain reaction (AP-PCR)...
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