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Article

Mutation of a mutL homolog in hereditary colon cancer.

Science (New York, N.Y.) - 18 Mar 1994

Papadopoulos N, Nicolaides N C, Wei Y F, Ruben S M, Carter K C, Rosen C A, Haseltine W A, Fleischmann R D, Fraser C M, Adams M D

Abstract excerpt

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene. One of these genes (hMLH1) resides on chromosome 3p21, within 1 centimorgan of markers...

Topics

Adaptor Proteins, Signal Transducing
Adenosine Triphosphatases
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Carrier Proteins
Chromosome Mapping
Chromosomes, Human, Pair 3
Codon
Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Repair

DNA-Binding Proteins

Escherichia coli Proteins

Female

Frameshift Mutation

Genes

Genetic Markers

Humans

Source

Identifiers

PMID: 8128251
DOI: 10.1126/science.8128251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8128251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutation of a mutL homolog in hereditary colon cancer.PMID 8128251Read ↗

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

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Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch RepairSemantic proximity Read ↗

Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.Semantic proximity Read ↗

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