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Article

Mutation of a mutL homolog in hereditary colon cancer.

Science (New York, N.Y.) - 18 Mar 1994

Papadopoulos N, Nicolaides N C, Wei Y F, Ruben S M, Carter K C, Rosen C A, Haseltine W A, Fleischmann R D, Fraser C M, Adams M D

Abstract excerpt

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene. One of these genes (hMLH1) resides on chromosome 3p21, within 1 centimorgan of markers...

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PMID: 8128251
DOI: 10.1126/science.8128251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutation of a mutL homolog in hereditary colon cancer.PMID 8128251Read ↗

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Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch RepairSemantic proximity Read ↗

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Mutations predisposing to hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

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